Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Some findings are held for review
Some papers have not cleared source or result review, so their findings are not summarized yet.
No confirmed result is available to summarize with study conditions.
A distinct publication count is not available.
Distinct publications linked to this topic: 2
The current data are insufficient to judge results for this topic.
Review findings reported in each research area.
Topics with more linked papers appear first.
Related papers 15 · human comparison papers 3
More outcome groups: 14
Related papers 7 · comparison findings need further review
More outcome groups: 5
Related papers 5 · human comparison papers 1
More outcome groups: 4
Related papers 3 · human comparison papers 1
More outcome groups: 3
Related papers 3 · human comparison papers 2
More outcome groups: 1
Related papers 2 · comparison findings need further review
Related papers 2 · comparison findings need further review
Related papers 1 · comparison findings need further review
Related papers 1 · comparison findings need further review
Related papers 1 · comparison findings need further review
Related papers 1 · comparison findings need further review
Related papers 1 · comparison findings need further review
Related papers 1 · comparison findings need further review
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: C
The 31.7 evidence score includes 0 independent human studies and 0 clinical studies in the representative benefit area. The C tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 131
Papers linked to this topic 2 · distinct papers 2 · comparison findings need further review · papers needing additional review 2
Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Results for this measurement were mixed; no consistent conclusion can be drawn.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Single ingredient · Patient group
Within-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Other evidence · Single ingredient · Unspecified population
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported in animal or cell research.
Animal study · indirect · Ingredient combination · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
The comparison could not be confirmed.
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported in animal or cell research.
Animal study · indirect · Ingredient combination · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported in animal or cell research.
Cell study · indirect · Ingredient combination · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Observational study · Unknown intervention · General population
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Other evidence · Single ingredient · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Separable contribution · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Results for this measurement were mixed; no consistent conclusion can be drawn.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Other evidence · Single ingredient · Patient group
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported in animal or cell research.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Unspecified population
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Results for this measurement were mixed; no consistent conclusion can be drawn.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported in animal or cell research.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Unspecified population
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Meta-analysis · Unknown intervention · Patient group
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Unspecified population
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Unspecified population
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Cell study · indirect · Unknown intervention · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Unspecified population
The comparison could not be confirmed.
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
These studies reported worsening outcomes, reduced absorption, or other cautions with combined use. They do not predict an individual's outcome.
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
The combination showed improvement, but each ingredient's contribution is unclear.