Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Vitamin E
Men's health
Human studies reported both between-group improvement and a within-group change for sperm motility; while Cell studies reported between-group improvement in sperm motility.
single- and combination-ingredient studies · Individual ingredient effects cannot be separated · Cell or in-vitro studies; indirect evidence · Includes human studies · Includes patient groups · between-group comparison · within-group comparison
Publications for this result: 3
Other outcomes and study details
Distinct publications linked to this topic: 15
- Study conditions differ; results are shown descriptively and are not pooled.
- Combination, formula, or class studies do not isolate this ingredient or establish synergy.
- Animal and cell findings are indirect evidence.
What has been studied?
Distinct human comparison papers: 3
Some studies tested several ingredients together. Those results cannot show this ingredient’s separate effect or establish synergy.
concentration of seminal fluid
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Combination study · after 3 months
Measurement and study conditions
- Controlled human study
- Controlled trial
- Ingredient combination
- Patient group
- Primary outcome
- Within-group comparison
- Timepoint: after 3 months
- Study comparison: pre-test versus post-test after the multi-ingredient vitamin/mineral regimen; no between-group compa
count
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Single ingredient · Eight weeks
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: Eight weeks
- Study comparison: Vitamin E versus placebo in men; within-person pre/post semen measures
IVF outcomes
- Comparison result:No clear difference from the comparison group was found.Patient group · Single ingredient · Eight weeks
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Secondary outcome
- Between-group comparison
- Timepoint: Eight weeks
- Study comparison: Vitamin E versus placebo in men; within-person pre/post semen measures
morphology
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Single ingredient · Eight weeks
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: Eight weeks
- Study comparison: Vitamin E versus placebo in men; within-person pre/post semen measures
Other measured outcomes (10)
motility
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Single ingredient · Eight weeks
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: Eight weeks
- Study comparison: Vitamin E versus placebo in men; within-person pre/post semen measures
post-thawing motility
Animal and cell research · indirect evidence
- A change was reported in animal or cell research.General population · Combination study
Measurement and study conditions
- Animal study · indirect
- Controlled trial
- Ingredient combination
- General population
- Secondary outcome
- Comparison unclear
- Animal or cell research
- Timepoint: After cryopreservation and thawing
- Study comparison: Beta-carotene plus alpha-tocopherol extender condition; abstract reports no effect on motility
rate of normal semen analysis results
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Patient group · Combination study
Measurement and study conditions
- Other evidence
- Ingredient combination
- Patient group
- Outcome role not specified
- Timepoint: unspecified
- Study comparison: unspecified
SDF
- Comparison result:Results were mixed for this outcome.Patient group · Combination study
Measurement and study conditions
- Controlled human study
- Randomized trial
- Ingredient combination
- Patient group
- Primary outcome
- Between-group comparison
- Timepoint: study follow-up duration not specified
- Between-group comparison
serum testosterone
Animal and cell research · indirect evidence
- A change was reported in animal or cell research.Patient group · Combination study · 28 days
Measurement and study conditions
- Animal study · indirect
- Controlled trial
- Ingredient combination
- Patient group
- Primary outcome
- Between-group comparison
- Animal or cell research
- Timepoint: 28 days
- Study comparison: tramadol plus vitamin E did not attenuate the reported testicular impairment relative to tramadol ex
sperm concentration
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Combination study · 3 months
Measurement and study conditions
- Other evidence
- Clinical trial
- Ingredient combination
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: 3 months
- Study comparison: Within-participant pre/post treatment; no between-group comparator
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Combination study · 3 months
Measurement and study conditions
- Other evidence
- Clinical trial
- Ingredient combination
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: 3 months
- Study comparison: Within-person change from baseline after combination formulation
sperm morphology
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Combination study
Measurement and study conditions
- Controlled human study
- Randomized trial
- Ingredient combination
- Unspecified population
- Outcome role not specified
- Timepoint: unspecified
- Study comparison: unspecified
sperm motility
Human comparison research
- Comparison result:A better result than the comparison group was reported.Patient group · Single ingredient
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Outcome role not specified
- Between-group comparison
- Timepoint: unspecified
- Study comparison: unspecified
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Single ingredient
Measurement and study conditions
- Other evidence
- Clinical trial
- Single ingredient
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: unspecified
- Study comparison: Within-treatment observation; comparator for motility not reported
Animal and cell research · indirect evidence
- A change was reported in animal or cell research.Patient group · Combination study · 75 minutes
Measurement and study conditions
- Cell study · indirect
- Controlled trial
- Ingredient combination
- Patient group
- Outcome role not specified
- Between-group comparison
- Animal or cell research
- Timepoint: 75 minutes
- Study comparison: First supplement mixture vs control
Sperm viability
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Single ingredient
Measurement and study conditions
- Other evidence
- Clinical trial
- Single ingredient
- Unspecified population
- Outcome role not specified
- Timepoint: unspecified
- Study comparison: unspecified
sperm volume
Other human research, including observational studies and reviews
- A change was reported before and after use. Its cause cannot be isolated.Patient group · Single ingredient · Eight weeks
Measurement and study conditions
- Controlled human study
- Randomized trial
- Single ingredient
- Patient group
- Secondary outcome
- Within-group comparison
- Timepoint: Eight weeks
- Study comparison: Vitamin E versus placebo in men; within-person pre/post semen measures
This result is held for interpretation. That does not mean research found no effect.
Outcome groups needing additional review (2)
- DNA-fragmented spermatozoa · Distinct papers needing additional review: 1Direction unclear: 1
- testosterone · Distinct papers needing additional review: 1Direction unclear: 1
One paper can appear under multiple measured outcomes or review reasons, so these counts should not be added together.
Research topics to explore
Research topics to explore
Review findings reported in each research area.
Topics with more linked papers appear first.
- View selected result
Men's health
Related papers 15 · human comparison papers 3
- View results
Immune and respiratory health
Related papers 7 · comparison findings need further review
- cytokine production · Interpretation held
- disease symptoms · Interpretation held
More outcome groups: 5
- View results
Blood lipids
Related papers 5 · human comparison papers 1
- cholesterol efflux · Improvement reported · Some studies included patients or people with a deficiency
- LP · Mixed results · Some studies included patients or people with a deficiency
More outcome groups: 4
- View results
Glucose and metabolic health
Related papers 3 · human comparison papers 1
- FBS · No clear difference between groups · Some studies included patients or people with a deficiency
- BMI · Comparison details unconfirmed
More outcome groups: 3
- View results
Nutrient status
Related papers 3 · human comparison papers 2
- Hemoglobin level · Improvement reported · Some studies included patients or people with a deficiency
- vitamin E level · No clear difference between groups · Some studies included patients or people with a deficiency
More outcome groups: 1
- View results
Cognition
Related papers 2 · comparison findings need further review
- cognitive and memory deficits · Interpretation held
- View results
Women's health
Related papers 2 · comparison findings need further review
- View results
Blood pressure and vascular health
Related papers 1 · comparison findings need further review
- DBP · Comparison details unconfirmed
- View results
Bone, joint, and mobility
Related papers 1 · comparison findings need further review
- serum C-terminal telopeptide of type I collagen (CTX) · Interpretation held
- View results
Migraine and pain
Related papers 1 · comparison findings need further review
- severity of pelvic pain · Interpretation held
- View results
Skin, hair, and nails
Related papers 1 · comparison findings need further review
- View results
Sleep
Related papers 1 · comparison findings need further review
- View results
Stress and mood
Related papers 1 · comparison findings need further review
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: C
The 31.7 evidence score includes 0 independent human studies and 0 clinical studies in the representative benefit area. The C tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 131
Papers linked to this topic 15 · distinct papers 15 · papers with a confirmed human comparison 3 · papers needing additional review 2
Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- concentration of seminal fluid: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- count: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- DNA-fragmented spermatozoa: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- IVF outcomes: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- morphology: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- motility: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- post-thawing motility: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- rate of normal semen analysis results: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- SDF: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 1
- serum testosterone: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- sperm concentration: Sources represented in this measurement group: 2 · Distinct papers with human comparisons for this outcome: 0
- sperm morphology: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- sperm motility: Sources represented in this measurement group: 3 · Distinct papers with human comparisons for this outcome: 1
- Sperm viability: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- sperm volume: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- testosterone: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
Men's health
What the research found
count
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
IVF outcomes
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
morphology
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
motility
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
SDF
Results for this measurement were mixed; no consistent conclusion can be drawn.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm volume
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
concentration of seminal fluid
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm motility
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm concentration
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm concentration
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm motility
A change was reported before and after use. Its cause cannot be isolated.
Other evidence · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
rate of normal semen analysis results
A change was reported, but the comparison could not be confirmed.
Other evidence · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm morphology
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Sperm viability
A change was reported, but the comparison could not be confirmed.
Other evidence · Single ingredient · Unspecified population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
post-thawing motility
A change was reported in animal or cell research.
Animal study · indirect · Ingredient combination · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
serum testosterone
A change was reported in animal or cell research.
Animal study · indirect · Ingredient combination · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
sperm motility
A change was reported in animal or cell research.
Cell study · indirect · Ingredient combination · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
DNA-fragmented spermatozoa
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
testosterone
The study needs further checking before its result can be interpreted.
Observational study · Unknown intervention · General population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Immune and respiratory health
What the research found
cytokine production
The study needs further checking before its result can be interpreted.
Other evidence · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
disease symptoms
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
immune boosting
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
inflammation markers
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
inflammatory response
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
liver anti-inflammatory factors
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
lung inflammation
The study needs further checking before its result can be interpreted.
Animal study · indirect · Separable contribution · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Blood lipids
What the research found
LP
Results for this measurement were mixed; no consistent conclusion can be drawn.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
cholesterol efflux
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
LDL oxidability
A change was reported, but the comparison could not be confirmed.
Other evidence · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
oxidized LDL
A change was reported in animal or cell research.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
apolipoprotein A-I (apo A-I)
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL sizes
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Patient group
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Glucose and metabolic health
What the research found
FBS
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HbA1c
Results for this measurement were mixed; no consistent conclusion can be drawn.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
BMI
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HbA1c
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
waist circumference (WC)
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
weight
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Nutrient status
What the research found
vitamin E level
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Hemoglobin level
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
total antioxidant status (TAS)
A change was reported in animal or cell research.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cognition
What the research found
cognitive and memory deficits
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Unspecified population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Women's health
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Blood pressure and vascular health
What the research found
DBP
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Unspecified population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Unspecified population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Bone, joint, and mobility
What the research found
serum C-terminal telopeptide of type I collagen (CTX)
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Migraine and pain
What the research found
severity of pelvic pain
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Skin, hair, and nails
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Cell study · indirect · Unknown intervention · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Sleep
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Stress and mood
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
Caution findings
2
Findings from individual and combined use, plus reviewed cautions
Key precautions
No reviewed caution rules are available yet. Reported caution findings are shown below.
Review 2 combination findings and 0 findings that outperformed an ingredient alone.
These findings were reported in studies. They do not predict an individual's experience.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Cautions reported with another supplement or medication
These studies reported worsening outcomes, reduced absorption, or other cautions with combined use. They do not predict an individual's outcome.
와파린Vitamin E's anticoagulant effects amplify the risk of bleeding when combined with blood thinners like warfarin.
AspirinVitamin E's anticoagulant effects amplify the risk of bleeding when combined with blood thinners like aspirin.
Reported improvements with combinations
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
Combinations with reported improvement
The combination showed improvement, but each ingredient's contribution is unclear.
비타민 CIn a triple-blind RCT of 60 women with endometriosis, a combination of Vitamin C (1000 mg/day) and Vitamin E (800 IU/day) for 8 weeks significantly reduced pelvic pain, dysmenorrhea, and dyspareunia compared to placebo.
인삼The combined supplement significantly improved the desire domain of the FSFI compared to placebo.