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Omega-3

Selected research topic

Blood lipids

Confirmed comparison evidence for this topic is limited. The findings below retain their study conditions.

Findings from a combination study cannot be attributed to this ingredient alone.

Some publications still need interpretation checks and are kept separate from the findings below.

Animal and cell findings do not establish the same effect in people.

Publications for this topic
7
Human comparison publications
0
Publications needing review
4

Findings in the studies

  • LDL cholesterol

    Other human research, including observational studies and reviews
    • An association was observed. This does not establish that the ingredient caused the change.
      General population · Single ingredient
      Measurement and study conditions
      • Observational study
      • Observational study
      • Single ingredient
      • General population
      • Biomarker
      • Comparison unclear
      • Timepoint: unspecified
      • Study comparison: fish-oil supplement use interaction with polygenic susceptibility

  • serum HDL's CEC

    Other human research, including observational studies and reviews
    • A change was reported before and after use. Its cause cannot be isolated.

      Several ingredients were tested together, so this ingredient’s individual effect is unknown.

      General population · Combination study · after 30 days
      Measurement and study conditions
      • Other evidence
      • Clinical trial
      • Ingredient combination
      • General population
      • Biomarker
      • Within-group comparison
      • Timepoint: after 30 days
      • Study comparison: within-group post-supplementation vs baseline

  • total cholesterol

    Other human research, including observational studies and reviews
    • An association was observed. This does not establish that the ingredient caused the change.
      General population · Single ingredient
      Measurement and study conditions
      • Observational study
      • Observational study
      • Single ingredient
      • General population
      • Biomarker
      • Comparison unclear
      • Timepoint: unspecified
      • Study comparison: fish-oil supplement use interaction with polygenic susceptibility

  • triglycerides

    Other human research, including observational studies and reviews
    • An association was observed. This does not establish that the ingredient caused the change.
      General population · Single ingredient
      Measurement and study conditions
      • Observational study
      • Observational study
      • Single ingredient
      • General population
      • Biomarker
      • Comparison unclear
      • Timepoint: unspecified
      • Study comparison: fish-oil supplement use interaction with polygenic susceptibility
Other measured outcomes (2)

  • cholesterol efflux

    Animal and cell research · indirect evidence
    • A change was reported in animal or cell research.
      extended in-vitro exposure
      Measurement and study conditions
      • Cell study · indirect
      • Controlled trial
      • Unknown intervention
      • Unspecified population
      • Mechanistic outcome
      • Comparison unclear
      • Animal or cell research
      • Timepoint: extended in-vitro exposure
      • Study comparison: Source-reported animal/cell result; result sentence does not identify a named comparator arm

  • ABCA1-mediated cholesterol efflux

    Research with unclear study subject or type
    • A change was reported, but the comparison could not be confirmed.
      Single ingredient
      Measurement and study conditions
      • Other evidence
      • Single ingredient
      • Unspecified population
      • Outcome role not specified
      • Study subject not identified
      • Timepoint: unspecified
      • Study comparison: unspecified

This result is held for interpretation. That does not mean research found no effect.

Outcome groups needing additional review (3)
  • HDL-C · Distinct papers needing additional review: 1Direction unclear: 1
  • plasma cholesterol · Distinct papers needing additional review: 1Evidence criteria check: 1
  • triglyceride level · Distinct papers needing additional review: 1Direction unclear: 1

One paper can appear under multiple measured outcomes or review reasons, so these counts should not be added together.

Representative outcome and study details

Studies with an unspecified organism reported a change with no confirmed comparison group in ABCA1-mediated cholesterol efflux.

Single-ingredient studies · Population not specified · comparator not confirmed

1 publications linked to this result

  • Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
Data coverage and detailed study classifications

Paper counts are separated by research topic below. One paper may contribute to multiple findings.

Analysis status: Public-ready

Ingredient analysis date:

How the grade was determined: C

The 50.0 evidence score includes 1 independent human studies and 1 clinical studies in the representative benefit area. The C tier remains conservative because of the evidence centers on contextual or measured outcomes rather than general-use effects, limited repetition across independent human clinical studies.

The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.

Papers linked to this ingredient overall: 115

Papers linked to this topic 7 · distinct papers 7 · comparison findings need further review · papers needing additional review 4

A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.

  • ABCA1-mediated cholesterol efflux: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • cholesterol efflux: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • HDL-C: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • LDL cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • plasma cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • serum HDL's CEC: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • total cholesterol: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • triglyceride level: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
  • triglycerides: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0

What the research found

LDL-C

An association was observed. This does not establish that the ingredient caused the change.

Observational study · Single ingredient · General population

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

serum HDL's CEC

A change was reported before and after use. Its cause cannot be isolated.

Other evidence · Ingredient combination · General population

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

Within-group comparison

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

total cholesterol

An association was observed. This does not establish that the ingredient caused the change.

Observational study · Single ingredient · General population

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

triglycerides

An association was observed. This does not establish that the ingredient caused the change.

Observational study · Single ingredient · General population

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

ABCA1-mediated cholesterol efflux

A change was reported, but the comparison could not be confirmed.

Other evidence · Single ingredient · Unspecified population

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

cholesterol efflux

A change was reported in animal or cell research.

Cell study · indirect · Unknown intervention · Unspecified population

This finding comes from animal or cell research. It does not establish the same effect in people.

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

HDL-C

The study needs further checking before its result can be interpreted.

Observational study · Single ingredient · General population

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

1 papers held from direction counts

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

plasma cholesterol

The study needs further checking before its result can be interpreted.

Animal study · indirect · Ingredient combination · Patient group

This finding comes from animal or cell research. It does not establish the same effect in people.

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

1 papers held from direction counts

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

triglyceride level

The study needs further checking before its result can be interpreted.

Other evidence · Ingredient combination · Patient group

Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

1 papers held from direction counts

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

Unspecified measured outcome

The study needs further checking before its result can be interpreted.

Controlled human study · Unknown intervention · Unspecified population

The comparison could not be confirmed.

Analysis coverage and paper counts

1 paper · 1 measured outcome

1 papers held from direction counts

Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.

How to read research findings

How should I read research findings?

Research guides

Side effects and combination findings

Findings from this ingredient alone are shown separately from those involving another supplement or medication.

No combination cautions are available to show in the current data. This does not guarantee safety.

Review 2 combination findings and 0 findings that outperformed an ingredient alone.

Reported improvements with combinations

Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.

Combinations with reported improvement

The combination showed improvement, but each ingredient's contribution is unclear.

비타민 DCombined vitamin D and omega-3 fatty acids showed a 31% reduction in autoimmune disease incidence compared to placebo, suggesting a potential additive effect.
알파리포산The combination of omega-3 fatty acids and alpha-lipoic acid showed significant benefits in slowing cognitive and functional decline compared to placebo or omega-3 alone.