Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Selenium
Stress and mood
Human studies reported a change with no confirmed comparison group in Depressive symptoms; while Studies with an unspecified organism reported a change with no confirmed comparison group in Depressive symptoms.
Single-ingredient studies · Human studies · Includes patient groups · comparator not confirmed
Publications for this result: 1
Other outcomes and study details
Distinct publications linked to this topic: 3
- Study conditions differ; results are shown descriptively and are not pooled.
What has been studied?
Distinct human comparison papers: 0
Depressive symptoms
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Patient group · Single ingredient
Measurement and study conditions
- Meta-analysis
- Meta-analysis
- Single ingredient
- Patient group
- Primary outcome
- Timepoint: not specified
- Study comparison: selenium supplementation meta-analysis; abstract summary does not identify comparator
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Patient group · Single ingredient
Measurement and study conditions
- Meta-analysis
- Meta-analysis
- Single ingredient
- Patient group
- Outcome role not specified
- Study subject not identified
- Timepoint: unspecified
- Study comparison: unspecified
postpartum depression
Other human research, including observational studies and reviews
- A change was reported, but the comparison could not be confirmed.Patient group · Single ingredient
Measurement and study conditions
- Meta-analysis
- Meta-analysis
- Single ingredient
- Patient group
- Secondary outcome
- Timepoint: not specified
- Study comparison: observational association between high selenium intake and postpartum depression risk; association i
This result is held for interpretation. That does not mean research found no effect.
Outcome groups needing additional review (1)
- beck depression inventory · Distinct papers needing additional review: 1Evidence criteria check: 1
One paper can appear under multiple measured outcomes or review reasons, so these counts should not be added together.
Research topics to explore
Research topics to explore
Review findings reported in each research area.
Topics with more linked papers appear first.
- View results
Glucose and metabolic health
Related papers 8 · human comparison papers 2
- Fasting Glucose · Improvement reported · Some studies included patients or people with a deficiency
- Fasting Insulin · Improvement reported · Some studies included patients or people with a deficiency
More outcome groups: 5
- View results
Cardiovascular events
Related papers 4 · human comparison papers 2
- Cardiovascular Mortality · Mixed results · Some studies used more than one ingredient · Some studies included patients or people with a deficiency
- CV mortality · Improvement reported · Some studies used more than one ingredient
- View selected result
Stress and mood
Related papers 3 · comparison findings need further review
- View results
Exercise performance
Related papers 2 · comparison findings need further review
- Athletic performance · Comparison details unconfirmed
- View results
Blood lipids
Related papers 1 · comparison findings need further review
- HDL · Comparison details unconfirmed
- HDL/TC ratio · Comparison details unconfirmed
More outcome groups: 5
- View results
Bone, joint, and mobility
Related papers 1 · comparison findings need further review
- BMD of the lumbar region · Interpretation held
- View results
Cognition
Related papers 1 · comparison findings need further review
- mini-mental score · Some studies included patients or people with a deficiency · Comparison details unconfirmed
- View results
Immune and respiratory health
Related papers 1 · comparison findings need further review
- IFN-γ · Animal or cell research · Comparison details unconfirmed
- View results
Men's health
Related papers 1 · comparison findings need further review
- motility · Interpretation held
- View results
Women's health
Related papers 1 · comparison findings need further review
- birth weight · Some studies included patients or people with a deficiency · Comparison details unconfirmed
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: C
The 32.7 evidence score includes 1 independent human studies and 1 clinical studies in the representative benefit area. The C tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 51
Papers linked to this topic 3 · distinct papers 3 · comparison findings need further review · papers needing additional review 2
Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- beck depression inventory: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- Depressive symptoms: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- postpartum depression: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
Glucose and metabolic health
What the research found
HbA1c
No clear difference in this measurement was found between the compared groups.
Controlled study in people · Single ingredient · Unspecified population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Fasting Glucose
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Fasting Insulin
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
T2D
Results for this measurement were mixed; no consistent conclusion can be drawn.
Meta-analysis · Unknown intervention · Unspecified population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HOMA-IR
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
metabolic syndrome
A change was reported, but the comparison could not be confirmed.
Review · Unknown intervention · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
risk for type 2 diabetes
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Unknown intervention · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Other evidence · Single ingredient · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled human study · Unknown intervention · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cardiovascular events
What the research found
cardiovascular mortality
Results for this measurement were mixed; no consistent conclusion can be drawn.
Controlled study in people · Ingredient combination · Deficiency group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
CV mortality
The study reported improvement in this measurement.
Controlled study in people · Ingredient combination · General population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
cardiovascular mortality
The study reported improvement in this measurement.
Review · Ingredient combination · Deficiency group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cardiovascular Mortality
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Stress and mood
What the research found
depressive symptoms
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Depressive symptoms
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
postpartum depression
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
beck depression inventory
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Exercise performance
What the research found
Athletic performance
A change was reported, but the comparison could not be confirmed.
Review · Single ingredient · Unspecified population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Blood lipids
What the research found
HDL
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL/TC ratio
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
LDL
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
non-HDL-C
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
TC
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
TG
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
VLDL
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Bone, joint, and mobility
What the research found
BMD of the lumbar region
The study needs further checking before its result can be interpreted.
Observational study · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cognition
What the research found
mini-mental score
A change was reported, but the comparison could not be confirmed.
Review · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Immune and respiratory health
What the research found
IFN-γ
A change was reported in animal or cell research.
Animal study · indirect · Single ingredient · General population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Men's health
What the research found
motility
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · General population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Women's health
What the research found
birth weight
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Unknown intervention · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
Caution findings
0
Findings from individual and combined use, plus reviewed cautions
Key precautions
No combination cautions are available to show in the current data. This does not guarantee safety.
Review 3 combination findings and 0 findings that outperformed an ingredient alone.
These findings were reported in studies. They do not predict an individual's experience.
Reported improvements with combinations
Combination findings are grouped by how the study compared them. This is not a recommendation to combine ingredients.
Combinations with reported improvement
The combination showed improvement, but each ingredient's contribution is unclear.
프로바이오틱스Co-supplementation with probiotics and selenium resulted in significant improvements in mental health, hormonal profiles, and oxidative stress markers compared to placebo.
코엔자임 Q10Combined supplementation with selenium and Coenzyme Q10 resulted in significantly improved renal function markers compared to placebo.
이노시톨Combined administration of myo-inositol and selenium significantly decreased TSH, TPOAb, and TgAb levels and enhanced thyroid hormones compared to baseline.