Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Niacin
Skin, hair, and nails
Some findings are held for review
Some papers have not cleared source or result review, so their findings are not summarized yet.
No confirmed result is available to summarize with study conditions.
A distinct publication count is not available.
Other outcomes and study details
Distinct publications linked to this topic: 2
- Those papers are not summarized until review is complete.
The current data are insufficient to judge results for this topic.
Research topics to explore
Research topics to explore
Review findings reported in each research area.
Topics with more linked papers appear first.
- View results
Blood lipids
Related papers 11 · human comparison papers 2
- LDL · Improvement reported · Some studies included patients or people with a deficiency
- Non-high-density lipoprotein cholesterol · Improvement reported · Some studies used more than one ingredient · Some studies included patients or people with a deficiency
More outcome groups: 5
- View results
Glucose and metabolic health
Related papers 5 · human comparison papers 2
- fasting glucose · Worsening reported · Some studies used more than one ingredient · Some studies included patients or people with a deficiency
- new-onset diabetes · Worsening reported · Some studies used more than one ingredient · Some studies included patients or people with a deficiency
- View results
Cardiovascular events
Related papers 4 · comparison findings need further review
- non-fatal myocardial infarction · Interpretation held
- View selected result
Skin, hair, and nails
Related papers 2 · comparison findings need further review
- View results
Stress and mood
Related papers 2 · comparison findings need further review
- anxious and depressed · Interpretation held
- depressive symptoms · Interpretation held
- View results
Blood pressure and vascular health
Related papers 1 · comparison findings need further review
- BP · Some studies included patients or people with a deficiency · Comparison details unconfirmed
- View results
Cognition
Related papers 1 · comparison findings need further review
- View results
Migraine and pain
Related papers 1 · comparison findings need further review
- migraine · Comparison details unconfirmed
- View results
Nutrient status
Related papers 1 · comparison findings need further review
- niacin · Interpretation held
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: C
The 16.3 evidence score includes 0 independent human studies and 0 clinical studies in the representative benefit area. The C tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 59
Papers linked to this topic 2 · distinct papers 2 · comparison findings need further review · papers needing additional review 2
Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
Blood lipids
What the research found
HDL cholesterol
A change was reported before and after use. Its cause cannot be isolated.
Controlled study in people · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
LDL
The study reported improvement in this measurement.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Non-high-density lipoprotein cholesterol
The study reported improvement in this measurement.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
high-density lipoprotein cholesterol
An association was observed. This does not establish that the ingredient caused the change.
Observational study · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
triglyceride reductions
The study reported improvement in this measurement.
Meta-analysis · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL cholesterol
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDL-C
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
HDLc
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Other evidence · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Glucose and metabolic health
What the research found
fasting glucose
The study reported worsening in this measurement.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
new-onset diabetes
The study reported worsening in this measurement.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
new-onset diabetes
A change was reported, but the comparison could not be confirmed.
Controlled study in people · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
new-onset diabetes
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · General population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cardiovascular events
What the research found
non-fatal myocardial infarction
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 2 measured outcomes
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Other evidence · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Skin, hair, and nails
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Ingredient combination · Patient group
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Stress and mood
What the research found
anxious and depressed
The study needs further checking before its result can be interpreted.
Other evidence · Single ingredient · Patient group
Within-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
depressive symptoms
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Patient group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Blood pressure and vascular health
What the research found
BP
A change was reported, but the comparison could not be confirmed.
Review · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cognition
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Migraine and pain
What the research found
migraine
An association was observed. This does not establish that the ingredient caused the change.
Observational study · Unknown intervention · General population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Nutrient status
What the research found
niacin
The study needs further checking before its result can be interpreted.
Review · Unknown intervention · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
Caution findings
2
Findings from individual and combined use, plus reviewed cautions
Key precautions
No reviewed caution rules are available yet. Reported caution findings are shown below.
These findings were reported in studies. They do not predict an individual's experience.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported with this ingredient alone
Symptoms or adverse events reported in studies without another active ingredient.
Cutaneous vasodilation (flushing)1 papers
Niacin causes cutaneous vasodilation (flushing) as a strong side effect when used to treat dyslipidemias.Human studies · Study type not identifiedCautions reported with another supplement or medication
These studies reported worsening outcomes, reduced absorption, or other cautions with combined use. They do not predict an individual's outcome.
스타틴Increased risk of all-cause mortality observed when niacin is combined with statins.