Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Iodine
Nutrient status
Studies with an unspecified organism reported a change with no confirmed comparison group in endemic goiter.
Single-ingredient studies · Includes deficiency groups · comparator not confirmed
Publications for this result: 1
Other outcomes and study details
Distinct publications linked to this topic: 4
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
What has been studied?
Distinct human comparison papers: 0
endemic goiter
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.Deficiency group · Single ingredient
Measurement and study conditions
- Review
- Review
- Single ingredient
- Deficiency group
- Outcome role not specified
- Study subject not identified
- Timepoint: Unspecified
- Study comparison: Historical iodine supplementation and endemic-goiter prevention
in vivo bioavailability
Research with unclear study subject or type
- A change was reported, but the comparison could not be confirmed.
Measurement and study conditions
- Meta-analysis
- Meta-analysis
- Unknown intervention
- Unspecified population
- Biomarker
- Study subject not identified
- Timepoint: unspecified
- Study comparison: review synthesis of in-vivo and in-vitro food-source bioavailability studies
severe iodine deficiency
Other human research, including observational studies and reviews
- An association was observed. This does not establish that the ingredient caused the change.Deficiency group
Measurement and study conditions
- Observational study
- Observational study
- Unknown intervention
- Deficiency group
- Primary outcome
- Comparison unclear
- Timepoint: after guideline implementation; timing unspecified
- Study comparison: Different cross-sectional samples before versus after regional supplementation-guideline implementat
Research topics to explore
Research topics to explore
Review findings reported in each research area.
Topics with more linked papers appear first.
- View selected result
Nutrient status
Related papers 4 · comparison findings need further review
- View results
Glucose and metabolic health
Related papers 3 · human comparison papers 1
- glucose uptake · Interpretation held
- type 2 diabetes · Finding details are limited
- View results
Cognition
Related papers 2 · comparison findings need further review
- child cognitive · Some studies included patients or people with a deficiency · Comparison details unconfirmed
- View results
Immune and respiratory health
Related papers 2 · comparison findings need further review
- View results
Women's health
Related papers 2 · comparison findings need further review
- maternal and child outcomes · Some studies included patients or people with a deficiency · Comparison details unconfirmed
- Maternal thyroglobulin · Some studies included patients or people with a deficiency · Comparison details unconfirmed
More outcome groups: 1
- View results
Blood lipids
Related papers 1 · comparison findings need further review
- View results
Digestion and gut health
Related papers 1 · comparison findings need further review
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 57.4 evidence score includes 0 independent human studies and 0 clinical studies in the representative benefit area. The B tier remains conservative because of limited repetition across independent human clinical studies, too few clinical findings with an explicit effect direction.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 72
Papers linked to this topic 4 · distinct papers 4 · comparison findings need further review · papers needing additional review 1
Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- endemic goiter: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- in vivo bioavailability: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
- severe iodine deficiency: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
Nutrient status
What the research found
severe iodine deficiency
An association was observed. This does not establish that the ingredient caused the change.
Observational study · Unknown intervention · Deficiency group
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
endemic goiter
A change was reported, but the comparison could not be confirmed.
Review · Single ingredient · Deficiency group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
in vivo bioavailability
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Unknown intervention · Unspecified population
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Review · Single ingredient · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Glucose and metabolic health
What the research found
type 2 diabetes
An association was observed. This does not establish that the ingredient caused the change.
Observational study · Unknown intervention · General population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
glucose uptake
The study needs further checking before its result can be interpreted.
Cell study · indirect · Ingredient combination · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Meta-analysis · Single ingredient · Unspecified population
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Cognition
What the research found
child cognitive
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Patient group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Unspecified population
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Immune and respiratory health
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Other evidence · Ingredient combination · Unspecified population
Several ingredients were used together. This does not establish the effect of this ingredient alone or synergy.
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Women's health
What the research found
maternal and child outcomes
A change was reported, but the comparison could not be confirmed.
Review · Unknown intervention · Deficiency group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Maternal thyroglobulin
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Deficiency group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Maternal thyroid volume
A change was reported, but the comparison could not be confirmed.
Meta-analysis · Single ingredient · Deficiency group
Analysis coverage and paper counts
1 paper · 1 measured outcome
Review overlap with primary papers is unknown; counts stay separate.
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Blood lipids
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Animal study · indirect · Single ingredient · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
Digestion and gut health
What the research found
Unspecified measured outcome
The study needs further checking before its result can be interpreted.
Controlled study in people · Single ingredient · Patient group
Between-group comparison
Analysis coverage and paper counts
1 paper · 1 measured outcome
1 papers held from direction counts
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
Caution findings
2
Findings from individual and combined use, plus reviewed cautions
Key precautions
No reviewed caution rules are available yet. Reported caution findings are shown below.
These findings were reported in studies. They do not predict an individual's experience.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported with this ingredient alone
Symptoms or adverse events reported in studies without another active ingredient.
Iodine toxicity1 papers
Excess iodine exposure from environmental contamination can cause serious physiological adverse effects in humans.Human studies · Systematic reviewCell viability1 papers
Higher concentrations of iodine (Lugol solution) induce cytotoxicity and apoptosis in pancreatic beta cells.Cell studies · Cell or in-vitro study