Improvement after a supplement is not the same as a comparative result
Start with the comparison. A before-and-after change alone cannot isolate the contribution of an ingredient.
Bacopa
Selected research topic
Immune and respiratory health
The available findings are indirect evidence from animal or cell research. They do not establish the same effects in people.
- Publications for this topic
- 1
- Human comparison publications
- 0
- Publications needing review
- 0
Findings in the studies
IL-1β, IL-6, COX-2, and iNOS
Animal and cell research · indirect evidence
- A change was reported in animal or cell research.Single ingredient
Measurement and study conditions
- Cell study · indirect
- Controlled trial
- Single ingredient
- Unspecified population
- Mechanistic outcome
- Comparison unclear
- Animal or cell research
- Timepoint: unspecified
- Study comparison: BME in primed cells; comparator not specified
Representative outcome and study details
Cell studies reported improvement in IL-1β, IL-6, COX-2, and iNOS.
Single-ingredient studies · Cell or in-vitro studies; human applicability unconfirmed · Population not specified · comparator not confirmed
1 publications linked to this result
- Route, form, dose, or population details are incomplete, so the findings cannot be confirmed as directly comparable.
- Animal and cell findings are indirect evidence.
Data coverage and detailed study classifications
Paper counts are separated by research topic below. One paper may contribute to multiple findings.
Analysis status: Public-ready
Ingredient analysis date:
How the grade was determined: B
The 60.3 evidence score includes 12 independent human studies and 11 clinical studies in the representative benefit area. The B tier reflects evidence directness, repetition, and consistency together.
The grade is based mainly on the research area with the most evidence. It does not mean the same result was found in other areas.
Papers linked to this ingredient overall: 72
Papers linked to this topic 1 · distinct papers 1 · comparison findings need further review · papers needing additional review 0
A publication may appear in more than one count. These numbers should not be added. Ingredient-wide papers, topic-linked papers, and sources in outcome groups use different scopes. Adding source counts may count the same paper more than once.
- IL-1β, IL-6, COX-2, and iNOS: Sources represented in this measurement group: 1 · Distinct papers with human comparisons for this outcome: 0
What the research found
IL-1β, IL-6, COX-2, and iNOS
A change was reported in animal or cell research.
Cell study · indirect · Single ingredient · Unspecified population
This finding comes from animal or cell research. It does not establish the same effect in people.
The comparison could not be confirmed.
Analysis coverage and paper counts
1 paper · 1 measured outcome
Direction counts are distinct papers within each row. Outcome contributions count endpoint results, so one paper may contribute more than once.
How to read research findings
How should I read research findings?
Research guidesNo clear difference and an uninterpretable result are different
A reported null comparison contains a result. An abstract without an interpretable comparison leaves a question unresolved.
Paper counts and study counts are different
Count original research separately from research that reanalyzes it. Publication volume is neither replication nor a quality rating.
Side effects and combination findings
Findings from this ingredient alone are shown separately from those involving another supplement or medication.
No reviewed caution rules are available yet. Reported caution findings are shown below.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported with this ingredient alone
Symptoms or adverse events reported in studies without another active ingredient.
Rey Auditory Verbal Learning Test (AVLT)1 papers
In a double-blind, placebo-controlled RCT, 300 mg/day Bacopa monnieri significantly improved verbal learning and memory acquisition in healthy older adults, though gastrointestinal side effects were reported.Human studies · Randomized controlled trial