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Tier-BPublic-ready6/30/2026

Zinc

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 60.0 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
51
Caution signal
Low
Context-specific research signal
60.0
Glucose and metabolic health markersImmune and respiratory supportBlood-Level or Deficiency Marker

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
5 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
56.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Immune and respiratory health
3 studiesTier-B
Immune and respiratory support
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Immune and respiratory health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
2 studiesTier-C
Blood-Level or Deficiency Marker
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
2 studiesTier-C
Menstrual and women's health
Signal is still limitedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
5.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
2.22
mg/day
Higher observed study value
34
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.6
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Non-serious adverse events (nausea, mouth/nasal irritation)1 papers
Non-serious adverse events such as nausea and mouth/nasal irritation were higher with zinc compared to placebo (RR 1.41, NNH=7, moderate-certainty).Human studies · Meta-analysis

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

마그네슘Co-supplementation with magnesium oxide and zinc sulfate resulted in significant improvements in glycemic control, lipid profiles, and inflammatory markers compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 256
review

A timely analysis proving the urgent necessity of the treatment of heavy metal pollution in lead-zinc mine tailings in China is provided.

Key Evidence #2
Public scholarly dataCitation signal: 233
observational

It is suggested that treatment with zinc, ascorbic acid, or both does not affect SARS-CoV-2 symptoms, and there was no significant difference in the duration of symptoms among the 4 groups.

Key Evidence #3
Public scholarly dataCitation signal: 141
observational

The notion that zinc supplementation may have clinical potential as an adjunct therapy for preventing or managing diabetes is supported, particularly the FG in subjects with diabetes and in subjects who received an inorganic zinc supplement.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 137
observational

Among a general population of couples seeking infertility treatment, the use of folic acid and zinc supplementation by male partners, compared with placebo, did not significantly improve semen quality or couples' live birth rates.

Public scholarly dataCitation signal: 124
observational

It is demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks to women with GDM may reduce biomarkers of inflammation and oxidative stress.

Public scholarly dataCitation signal: 112
review

A direct relationship was found between serum/plasma zinc levels and T2DM and a moderately high dietary zinc intake, in relation to the Dietary Reference Intake, could reduce by 13% the risk of T1DM, and up to 41% in rural areas, suggesting disturbances in zin

Zinc
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