biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready6/28/2026

Vitamin D

Immune and respiratory support is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
114
Caution signal
Low
Representative score
58.7
Immune and respiratory supportGlucose and metabolic health markersExercise performance and recovery

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Immune and respiratory health
5 studiesTier-B
Immune and respiratory support
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Immune and respiratory health.

Evidence score
66.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health
6 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
58.5
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery
2 studiesTier-C
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
1 studiesTier-C
Blood-Level or Deficiency Marker
Some positive signal observedResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
22.8
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
400
IU/day
Higher observed study value
10000
IU/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
1.0
Caution band: Low
Caution signals
7
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
0 combo signals and 1 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

renal failure, cardiac arrhythmia, status epilepticus1 papers
Chronic and high-dose vitamin D therapy can lead to life-threatening complications including renal failure, cardiac arrhythmia, and status epilepticus.Human studies · Meta-analysis
kidney stones1 papers
Kidney stones occurred in 32 participants receiving vitamin D3 compared to 26 receiving placebo, suggesting a potential adverse effect.Human studies · Randomized controlled trial
Faller rate in subgroup with fall history1 papers
High doses of vitamin D (4000, 4800 IU/day) increased fall rates compared to medium doses (Odds Ratio 5.6, 95% CI: 2.1-14.8) in elderly women with a fall history, suggesting a potential adverse effect.Human studies · Randomized controlled trial
Adverse reactions (hypercalciuria, hypervitaminosis D, kidney stones, gastrointestinal symptoms, mild itch)1 papers
Six studies reported adverse reactions potentially attributable to vitamin D, including hypercalciuria, hypervitaminosis D, kidney stones, gastrointestinal symptoms, and mild itch, occurring across both treatment and control arms.Human studies · Meta-analysis
Adverse effect signal1 papers
The review mentions that vitamin D toxicity may manifest as fatigue, muscle weakness, or urinary dysfunction.Human studies · Study type not identified

Caution signals when used with another supplement or medication

These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.

대기 오염The review reports that air pollution may reduce vitamin D cutaneous production by blocking ultraviolet B photons or decreasing outdoor activity, leading to vitamin D deficiency.
내분비 교란 화학물질The review states that endocrine-disrupting chemicals may inhibit cytochrome P450 activity and expression, indirectly causing vitamin D deficiency through weight gain and hormone dysregulation.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Combinations that performed better than solo use

Shown only when a study directly compared the combination with an ingredient used alone and found a better result.

오메가-3Combined vitamin D and omega-3 fatty acids showed a 31% reduction in autoimmune disease incidence compared to placebo, suggesting a potential additive effect.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 1733
review

Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall and patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

Key Evidence #2
Public scholarly dataCitation signal: 793
observational

It is concluded that vitamin D supplementation of 4000 IU/d for pregnant women is safe and most effective in achieving sufficiency in all women and their neonates regardless of race, whereas the current estimated average requirement is comparatively ineffectiv

Key Evidence #3
Public scholarly dataCitation signal: 600
observational

This study shows proof-of-principle that specific nutritional supplementation alone might benefit geriatric patients, especially relevant for those who are unable to exercise.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 568
observational

Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D3 supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo.

Public scholarly dataCitation signal: 549
meta-analysis

This meta-analysis of RCTs supports the use of calcium plus vitamin D supplements as an intervention for fracture risk reduction in both community-dwelling and institutionalized middle-aged to older adults.

Public scholarly dataCitation signal: 361
observational

It is suggested that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density, and there is little justification to use vitamin D supplements to maintain or improve musculoskeletal health.

Vitamin D
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