Glucose and metabolic health
Glucose and metabolic health markers
Goal tierNot rated yet
No direct evidence for general supplement use is confirmed under the current standard.
Check this goal in more detailPublic-ready6/28/2026
Vitamin C
Papers analyzed
106
Glucose and metabolic health markersCholesterol and triglyceridesBlood-Level or Deficiency Marker
Main benefit evidence
Review human evidence by goal.
Blood lipids
Cholesterol and triglycerides
Goal tierNot rated yet
No direct evidence for general supplement use is confirmed under the current standard.
Check this goal in more detailNutrient status and deficiency
Blood-Level or Deficiency Marker
Goal tierNot rated yet
No direct evidence for general supplement use is confirmed under the current standard.
Check this goal in more detailImmune and respiratory health
Immune and respiratory support
Goal tierNot rated yet
No direct evidence for general supplement use is confirmed under the current standard.
Check this goal in more detailBone and joint health
Bone, joint, and mobility
Goal tierNot rated yet
The currently linked research coverage is not broad enough to characterize this goal yet.
Check this goal in more detailBlood pressure and vascular health
Blood pressure and vascular health markers
Goal tierNot rated yet
The currently linked research coverage is not broad enough to characterize this goal yet.
Check this goal in more detailSide effects and combination findings in studies
Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.
Caution signals
5
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported when this ingredient was used alone
Symptoms or adverse events reported in studies of this ingredient without another active ingredient.
Adverse effect signal1 papers
High-dose vitamin C therapy has been reported to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients, and a case series in burn patients identified calcium oxalate nephropathy after high-dose vitamin C therapy.Human studies · Study type not identifiedAdverse effect signal1 papers
High-dose vitamin C supplementation is reported to increase urinary oxalate, which may increase the risk of hyperoxaluria and oxalate kidney stones.Human studies · Study type not identifiedAdverse effect signal1 papers
Contraindications for high-dose ascorbic acid are mentioned, including calcium oxalate urolithiasis, phenylketonuria, primary hemochromatosis, G6PD deficiency, and thalassemia.Human studies · Study type not identifiedAdverse effect signal1 papers
High-dose ascorbic acid is reported to increase serotonin via tryptophan hydrolysis, which may cause sensitization to pain through pro-nociceptive serotonin receptors.Human studies · Study type not identifiedAdverse effect signal1 papers
Calcium ascorbate EC showed better tolerability and fewer epigastric adverse events compared to ascorbic acid.Human studies · Study type not identifiedPositive combinations studied
Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.
Positive findings when used together
The combination had a positive result, but the contribution of each ingredient could not be separated.
비타민 EIn a triple-blind RCT of 60 women with endometriosis, daily supplementation with 1000 mg Vitamin C and 800 IU Vitamin E for 8 weeks significantly reduced pelvic pain, dysmenorrhea, and dyspareunia (p < 0.001) compared to placebo.
Vitamin C
arrow_backBack to list