biotech

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Tier-CPublic-ready6/29/2026

Vitamin A

Blood-Level or Deficiency Marker is closer to a research marker, so it should be read separately from a directly felt benefit.

The 44.0 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the C tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
63
Caution signal
Low
Context-specific research signal
44.0
Blood-Level or Deficiency MarkerMenstrual and women's health

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Nutrient status and deficiency
3 studiesTier-C
Blood-Level or Deficiency Marker
Some positive signal observedResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
35.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
1 studiesTier-C
Menstrual and women's health
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
20.9
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
100
mcg/day
Higher observed study value
700
mcg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
2
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Hypervitaminosis A risk1 papers
The study notes that preformed vitamin A from supplementation and fortification carries a potential for hypervitaminosis A, which biofortified maize could avoid.Human studies · Randomized controlled trial
Vomiting1 papers
Vitamin A supplementation is associated with an increased risk of vomiting within the first 48 hours of administration.Human studies · Meta-analysis

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 507
observational

New evidence for both prevalence and absolute burden of vitamin A deficiency should be used to reconsider, and possibly revise, the list of priority countries for high-dose vitamin A supplementation such that a country's priority status takes into account both

Key Evidence #2
Public scholarly dataCitation signal: 445
review

There is no evidence to support the use of vitamin and antioxidant supplements for prevention of cardiovascular diseases.

Key Evidence #3
Public scholarly dataCitation signal: 345
review

Vitamin A supplementation is associated with large reductions in mortality, morbidity, and vision problems in a range of settings, and these results cannot be explained by bias.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 336
unknown

The Panel on Dietetic Products, Nutrition and Allergies derived Dietary Reference Values for vitamin A based on a factorial approach and considered that a concentration of 7 20 μg retinol/g liver can be used as a target value for establishing the Average Requi

Public scholarly dataCitation signal: 256
observational

Five years after the clinical trial ended, the beneficial effects of the AREDS formulation persisted for development of NV AMD but not for CGA, consistent with the original recommendations that persons with intermediate AMD or advanced AMD in one eye should co

Public scholarly dataCitation signal: 248
review

This review summarizes the effort to build the evidence base and breed 42 OFSP varieties to address widespread vitamin A deficiency in SSA using an integrated agriculture-nutrition approach and describes how the changing policy environment influenced the proce

Vitamin A
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