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Tier-BPublic-ready6/30/2026

Selenium

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
51
Caution signal
Low
Representative score
60.0
Glucose and metabolic health markersCholesterol and triglyceridesStress Response and Sleep Changes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
7 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
60.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
5 studiesTier-B
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
54.1
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Skin, hair, and nails
1 studiesTier-C
Skin, hair, and nail support
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Skin, hair, and nails. These findings come from a defined study population, so everyday effects may differ.

Evidence score
22.8
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
1 studiesTier-C
Blood-Level or Deficiency Marker
Some positive signal observedResearch marker focusSupplement context

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
22.8
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
3 studiesTier-C
Menstrual and women's health
Signal is still limitedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
1.5
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
83
mcg/day
Higher observed study value
200
mcg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Caution signals when used with another supplement or medication

These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.

Omega-3 Fatty AcidsThe multinutrient supplement contained omega-3 fatty acids, folic acid, vitamin D3, and calcium alongside selenium; no specific interaction with selenium was reported.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

프로바이오틱스Co-supplementation with probiotics and selenium resulted in significant improvements in mental health, hormonal profiles, and oxidative stress markers compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 334
observational

Selenium supplementation, compared with the placebo, significantly reduced serum high sensitivity C-reactive protein (hs-CRP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) and total-/HDL-cholesterol ratio, and significantly increas

Key Evidence #2
Public scholarly dataCitation signal: 249
review

The antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia is reviewed.

Key Evidence #3
Public scholarly dataCitation signal: 188
observational

Based on the study results, nano-Se especially synthesized by the biological method at diet levels of 25 or 50 mg/kg improved the growth performance, kidney and liver functions, carcass traits, antioxidants indices, and inflammatory cytokines of growing rabbit

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 157
observational

Antioxidants do not improve semen parameters or DNA integrity among men with male factor infertility, and this study suggests that antioxidant treatment of the male partner does not improve in vivo pregnancy or live birth rate.

Public scholarly dataCitation signal: 150
observational

The present estimated intake data can be used to examine a specific trace element of interest and would afford enhanced health protection from those trace elements characterized by both nutritional and toxicological effects.

Public scholarly dataCitation signal: 133
observational

Overall, the co-administration of probiotic and selenium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, TAC, GSH and MDA levels.

Selenium
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