biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready6/29/2026

Riboflavin

Pain, headache, and migraine is the main area connected here, and any felt benefit should be read together with the human evidence base.

The 54.4 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
130
Caution signal
Low
Context-specific research signal
54.4
Pain, headache, and migraineStress Response and Sleep ChangesBlood-Level or Deficiency Marker

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Pain and headache
3 studiesTier-B
Pain, headache, and migraine
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Pain and headache. These findings come from a defined study population, so everyday effects may differ.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
1 studiesTier-C
Stress Response and Sleep Changes
Some positive signal observedFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
1 studiesTier-C
Blood-Level or Deficiency Marker
Some positive signal observedResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
20.9
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
0.37
mg/day
Higher observed study value
400
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.6
Caution band: Low
Caution signals
2
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Skin necrosis and cell viability1 papers
Riboflavin hyperaccumulation by a fungal pathogen in bats causes cytotoxicity, cell necrosis, and exacerbates skin infection to necrosis during hibernation.Animal studies · Study type not identified
Adverse effects (weight gain, dizziness, gastrointestinal problems)1 papers
In a single-blind RCT of 90 migraine patients, Riboflavin (400 mg/day) resulted in significantly fewer adverse effects compared to sodium valproate (p = 0.005), while showing similar efficacy in reducing migraine frequency and severity.Human studies · Randomized controlled trial

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 164
review

The crucial role of riboflavin for general human health, and the clear benefits of rib oflavin treatment in patients with inborn errors of metabolism are described.

Key Evidence #2
Public scholarly dataCitation signal: 156
observational

Treatment with a proprietary nutritional supplement containing magnesium, riboflavin and Q10 had an impact on migraine frequency which showed a trend towards statistical significance and Migraine symptoms and burden of disease were statistically significantly

Key Evidence #3
Public scholarly dataCitation signal: 129
observational

This review focuses on the clinical and biochemical features associated with biallelic FLAD1 mutations leading to FAD synthase deficiency, the only known primary defect in flavocoenzyme synthesis, in addition to providing an overview of clinical disorders asso

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 124
observational

The results reveal that the majority of pregnant women in these two counties of rural Shaanxi had low intakes of nutrients that are essential for pregnancy such as iron and folate.

Public scholarly dataCitation signal: 111
observational

A new MR1-restricted TCR is identified that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin, which suggests that TRAV12-2+ clone recognizes unique antigens.

Public scholarly dataCitation signal: 105
observational

Riboflavin and UV light effectively reduced the titer of SARS-CoV-2 to the limit of detection in human plasma and by 3.30 ± 0.26 on average in whole blood.

Riboflavin
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