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Public-ready7/5/2026

Rhodiola

Papers analyzed
92
Exercise performance and recoveryFatigue and energyStress Response and Sleep Changes

Main benefit evidence

Review human evidence by goal.

Exercise performance and recovery
Exercise performance and recovery
Goal tierC
Direct human evidence
Limited2 direct studies
Positive
2
No clear difference
0
Mixed
0
Negative
0
Research intake observed
One study used 3 mg/kg.
Dose confirmed in 1 of 2 direct studies.
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3 mg/kg
rct
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Fatigue and energy
Fatigue and energy
Goal tierC
Direct human evidence
Limited1 direct studies
Positive
1
No clear difference
0
Mixed
0
Negative
0
Research intake observed
Research intake was not verifiable in the available source text.
Check this goal in more detail
Stress and mood
Stress Response and Sleep Changes
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

1 human studies in a specific clinical context are available separately.

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Cognition and focus
Cognition, memory, and focus
Goal tierC
Direct human evidence
Limited1 direct studies
Positive
1
No clear difference
0
Mixed
0
Negative
0
Research intake observed
One study used 3 mg/kg.
Dose confirmed in 1 of 1 direct studies.
View study intake details
3 mg/kg
rct
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Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
4
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Adverse effect signal1 papers
The review states that Rhodiola rosea extracts may influence the metabolism of other drugs by inhibiting cytochrome P450 enzymes (CYP2C9, CYP2D6, CYP3A4) and P-gp activity, increasing the risk of unwanted interactions.Human studies · Study type not identified
Adverse Events1 papers
Rhodiola rosea resulted in significantly fewer adverse events (30.0%) compared to sertraline (63.2%) with a p-value of 0.012, indicating better tolerability.Human studies · Randomized controlled trial

Caution signals when used with another supplement or medication

These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.

SSRIsPotential risk of serotonin syndrome when combined with SSRIs.
Tricyclic antidepressantsPotential risk of serotonin syndrome when combined with tricyclic antidepressants.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

CaffeineA randomized, double-blind, placebo-controlled trial in 48 male volleyball players found that combined Rhodiola rosea and caffeine supplementation significantly improved jump height, reduced power decline during high-frequency jumps, and lowered perceived exertion compared to placebo and single-agent groups.
Rhodiola
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