Potassium

Tier-BPublic-ready6/30/2026

Blood pressure and vascular health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 62.7 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Low

Context-specific research signal

62.7

Blood pressure and vascular health markersGlucose and metabolic health markersHeart and cardiovascular outcomes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Blood pressure and vascular health

7 studiesTier-B

Blood pressure and vascular health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

60.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health

2 studiesTier-C

Glucose and metabolic health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

48.7

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Cardiovascular outcomes

1 studiesTier-C

Heart and cardiovascular outcomes

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Cardiovascular outcomes. These findings come from a defined study population, so everyday effects may differ.

Evidence score

44.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index

0.9

Caution band: Low

Caution signals

Side effects + combos + curated rules

Key precautions

No curated contraindication rule is available yet, but literature caution signals are shown below.

These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Methaemoglobin level1 papers

The panel concluded that increased methaemoglobin levels observed in humans and animals are a relevant adverse effect for deriving the Acceptable Daily Intake of potassium nitrite.Human studies · Systematic review

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 1140

observational

It is demonstrated that NEK7 is an essential protein that acts downstream of potassium efflux to mediate NLRP3 inflammasome assembly and activation.

Key Evidence #2

Public scholarly dataCitation signal: 1033

observational

The folding structure of the human telomeric sequence in K+ solution determined by NMR demonstrates a novel, unprecedented intramolecular G-quadruplex folding topology with hybrid-type mixed parallel/antiparallel G-strands, and suggests a straightforward pathw

Key Evidence #3

Public scholarly dataCitation signal: 585

review

[Abstract]: G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow syn

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 404

observational

Conference deliberations on potassium homeostasis in health and disease, guidance for evaluation and management of dyskalemias in the context of kidney diseases, and research priorities in each of the above areas are provided.

Public scholarly dataCitation signal: 271

observational

An inexpensive and high-efficiency aldol condensation method under ambient temperature and pressure was proposed for the large-scale synthesis of CDs and the N-doped CF (NCF700) exhibits superior electrochemical energy storage performance for potassium ion bat

Public scholarly dataCitation signal: 230

observational

The high prevalence of hypokalemia among patients with coronavirus disease 2019 suggests the presence of disordered rennin-angiotensin system activity, which is increased as a result of the reduced counteractivity of angiotens in-converting enzyme 2,which is b

Potassium

Evidence score: 62.7|Caution index: 0.9

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