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Public-ready6/30/2026

Magnesium

Papers analyzed
50
Glucose and metabolic health markersStress Response and Sleep ChangesCholesterol and triglycerides

Main benefit evidence

Review human evidence by goal.

Glucose and metabolic health
Glucose and metabolic health markers
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

2 human studies in a specific clinical context are available separately.

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Stress and mood
Stress Response and Sleep Changes
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Blood lipids
Cholesterol and triglycerides
Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

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Blood pressure and vascular health
Blood pressure and vascular health markers
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Digestion and gut health
Digestion and gut comfort
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

2 human studies in a specific clinical context are available separately.

Check this goal in more detail

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
2
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
5 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Gastrointestinal Adverse Effects1 papers
The study reported a higher incidence of gastrointestinal adverse effects in the magnesium group (35 subjects) compared to the placebo group (9 subjects).Human studies · Randomized controlled trial
Diarrhea1 papers
The magnesium oxide group experienced a higher dropout rate (27% vs 17%) primarily due to diarrhea, a mild adverse event.Human studies · Randomized controlled trial

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

비타민 B6In subjects with severe/extremely severe stress, the combination of magnesium and vitamin B6 resulted in a 24% greater improvement compared to magnesium alone (p=0.0203).
비타민 DCo-supplementation with Vitamin D and Magnesium resulted in significant improvements in behavioral function and mental health scores compared to placebo.
MelatoninCombined melatonin and magnesium supplementation was more effective in improving serum levels of insulin compared to baseline.
CholineCo-supplementation of choline and magnesium was more effective in improving inflammation and endothelial dysfunction than either alone.
아연Co-supplementation with magnesium oxide and zinc sulfate resulted in significant improvements in glycemic control, lipid profiles, and inflammatory markers compared to placebo.
Magnesium
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