Magnesium

Tier-BPublic-ready6/30/2026

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 58.7 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Low

Context-specific research signal

58.7

Glucose and metabolic health markersStress Response and Sleep ChangesCholesterol and triglycerides

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health

8 studiesTier-B

Glucose and metabolic health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

61.4

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood

3 studiesTier-B

Stress Response and Sleep Changes

Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score

52.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids

2 studiesTier-C

Cholesterol and triglycerides

Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score

48.7

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood pressure and vascular health

1 studiesTier-C

Blood pressure and vascular health markers

Some positive signal observedResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

42.1

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health

2 studiesTier-C

Digestion and gut comfort

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score

39.7

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value

248

mg/day

8 independent studies

Higher observed study value

500

mg/day

Only ranges repeated in human, oral, single-ingredient studies are shown.

Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index

0.8

Caution band: Low

Caution signals

Side effects + combos + curated rules

Key precautions

No curated contraindication rule is available yet, but literature caution signals are shown below.

4 combo signals and 0 added-signal combos shown below.

These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Coronary Artery Calcification Score1 papers

In a randomized, double-blinded, placebo-controlled trial of 148 patients with predialysis CKD, oral magnesium supplementation (30 mmol/day) for 12 months significantly increased plasma magnesium but failed to slow the progression of vascular calcification and was associated with a higher incidence of serious adverse events including death and cardiovascular events.Human studies · Randomized controlled trial

Treatment-related adverse events1 papers

17.4% of subjects treated with magnesium alone experienced adverse events potentially related to treatment.Human studies · Randomized controlled trial

Gastrointestinal Adverse Effects1 papers

The study reported a higher incidence of gastrointestinal adverse effects in the magnesium group (35 subjects) compared to the placebo group (9 subjects).Human studies · Randomized controlled trial

Diarrhea1 papers

The magnesium oxide group experienced a higher dropout rate (27% vs 17%) primarily due to diarrhea, a mild adverse event.Human studies · Randomized controlled trial

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

비타민 B6In subjects with severe/extremely severe stress, the combination of magnesium and vitamin B6 resulted in a 24% greater improvement compared to magnesium alone (p=0.0203).

비타민 DCo-supplementation with Vitamin D and Magnesium resulted in significant improvements in behavioral function and mental health scores compared to placebo.

MelatoninCombined melatonin and magnesium supplementation was more effective in improving serum levels of insulin compared to baseline.

CholineCo-supplementation of choline and magnesium was more effective in improving inflammation and endothelial dysfunction than either alone.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 219

meta-analysis

Increasing dietary magnesium intake is associated with a reduced risk of stroke, heart failure, diabetes, and all-cause mortality, but not CHD or total CVD, which supports the notion that increasing dietary magnesium might provide health benefits.

Key Evidence #2

Public scholarly dataCitation signal: 152

observational

[Abstract]: Background: Nearly 50% of older adults have insomnia, with difficulty in getting to sleep, early awakening, or feeling unrefreshed on waking. With aging, several changes occur that can place one at risk for insomnia, including age-related changes i

Key Evidence #3

Public scholarly dataCitation signal: 151

review

Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples, however, the quality of the existing evidence is poor.

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 150

observational

Data suggest that VitK2 supplementation might improve bone quality and reduce fracture risk in osteoporotic patients, potentially enhancing the efficacy of Ca ± vitD and Mg supplementation, but data regarding the effectiveness of vitK2 and MG supplementation o

Public scholarly dataCitation signal: 140

review

From the available evidence, it emerged that supplementation with magnesium could be beneficial, however, the results are not univocal, both in terms of the plasma levels and of therapeutic effects.

Public scholarly dataCitation signal: 129

observational

MgO, but not AST-120, appears to be effective in slowing CAC progression in CKD, and larger-scale trials are warranted to confirm these findings.

Magnesium

Evidence score: 58.7|Caution index: 0.8

arrow_backBack to list