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arrow_backExplore/Iodine
Tier-CPublic-ready6/30/2026

Iodine

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 48.0 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the C tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
72
Caution signal
Low
Context-specific research signal
48.0
Glucose and metabolic health markersMenstrual and women's health

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
2 studiesTier-C
Menstrual and women's health
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
37.4
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range comes from human studies in general supplement-use contexts.

Lower observed study value
150
mcg/day
Higher observed study value
596.8
mcg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Adverse Events (Abortion, Blighted Ovum, Intrauterine Death, Neonatal Death)1 papers
The frequency of adverse events (abortion, blighted ovum, intrauterine death, neonatal death) did not differ between iodine and placebo groups during gestation or at delivery.Human studies · Randomized controlled trial

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 280
observational

The association between excess iodine intake and thyroid function is described and guidance on choice of biomarkers to assess iodine intake is provided, with an emphasis on the median urinary iodine concentration (UIC) and thyroglobulin.

Key Evidence #2
Public scholarly dataCitation signal: 218
review

It is indicated that nationally representative data are needed to guide the development of nutrition interventions and public health programs, such as dietary diversification, micronutrient fortification and supplementation.

Key Evidence #3
Public scholarly dataCitation signal: 131
meta-analysis

Although universal salt iodization has improved goiter rates, chronic exposure to excess iodine from water or poorly monitored salt are risk factors for hypothyroidism in free-living populations.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 122
observational

Daily iodine supplementation in mildly iodine-deficient pregnant women had no effect on child neurodevelopment at age 5-6 years and was randomised using mixed-effects models.

Public scholarly dataCitation signal: 116
observational

Fetal brain development is vulnerable to mild to moderate iodine deficiency, particularly in the first trimester, and potential randomized controlled trials investigating the effect of iodine supplementation in women with mild tomoderate iodine deficiency on c

Public scholarly dataCitation signal: 90
observational

There is insufficient good-quality evidence to support current recommendations for iodine supplementation in pregnancy in areas of mild-to-moderate deficiency, and well-designed RCTs, with child cognitive outcomes, are needed in pregnant women who are moderate

Iodine
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