Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.
The 54.4 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.
Representative tier calculated from paper evidence that passed the collection audit.
The representative ingredient tier is calculated from these target-level evidence groups.
Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.
This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.
This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.
This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.
This range includes studies in specific patient groups. It is not a general dose or recommendation.
Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Symptoms or adverse events reported in studies of this ingredient without another active ingredient.
These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.
Paper IDs and full lists are private. Only study types and summaries are shown.
The results of the first comparison, involving 6708 births with information on NTDs and other infant outcomes, show a protective effect of daily folic acid supplementation (alone or in combination with other vitamins and minerals) in preventing N TDs compared
It is indicated that nationally representative data are needed to guide the development of nutrition interventions and public health programs, such as dietary diversification, micronutrient fortification and supplementation.
In this small trial of children with non-syndromic ASD and language impairment, treatment with high-dose folinic acid for 12 weeks resulted in improvement in verbal communication as compared with placebo, particularly in those participants who were positive fo
Folic acid's putative role in influencing the acquisition of epigenetic marks in the germline, acquired during embryogenesis, is discussed, as well as the role of FA in the management of cancerous disease.
Folate status data for WRA globally are limited and must be carefully interpreted due to methodological issues, and future surveys would benefit from using the microbiologic assay to assess folate status, along with assay‐matched cutoffs to improve monitoring
The human gut appears to have a very efficient capacity to convert reduced dietary folates to 5-MTHF but limited ability to reduce folic acid, which would suggest that humans are reliant on the liver for folic Acid reduction even though it has a low and highly