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arrow_backExplore/Coenzyme Q10
Tier-CPublic-ready6/30/2026

Coenzyme Q10

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
102
Caution signal
Low
Representative score
56.5
Glucose and metabolic health markersCholesterol and triglyceridesPain, headache, and migraine

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
4 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
54.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
3 studiesTier-B
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Pain and headache
2 studiesTier-C
Pain, headache, and migraine
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Pain and headache. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery
1 studiesTier-C
Exercise performance and recovery
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Fatigue and energy
1 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusSupplement context

Potential benefit studied in Fatigue and energy.

Evidence score
44.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
1 studiesTier-C
Menstrual and women's health
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
50
mg/day
Higher observed study value
1200
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
2 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Adverse effect signal1 papers
Caution is advised for patients with glomerular filtration rate <60mL/min when using the combination of polyprenols and Coenzyme Q10.Human studies · Study type not identified

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

SeleniumCombined supplementation with selenium and coenzyme Q10 was associated with preservation of leukocyte telomere length and reduced cardiovascular mortality in a double-blind, placebo-controlled trial.
CurcuminA randomized controlled trial of 100 migraine patients found that 300 mg/day of Coenzyme Q10 combined with 80 mg/day of nano-curcumin significantly reduced migraine frequency, severity, and duration compared to control groups (P < 0.001) with no reported side effects.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 203
observational

CoQ10 supplementation does not reduce muscle pain in patients with statin myalgia and only 36% of patients complaining of statin myalgia develop symptoms during a randomized, double-blind crossover of statin vs placebo.

Key Evidence #2
Public scholarly dataCitation signal: 192
observational

Pretreatment with CoQ10 improves ovarian response to stimulation and embryological parameters in young women with poor ovarian reserve in IVF-ICSI cycles and further work is required to determine whether there is an effect on clinical treatment endpoints.

Key Evidence #3
Public scholarly dataCitation signal: 146
review

This review focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmon

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 141
observational

[Abstract]: Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin‐induced myopathy. However, whether CoQ10 supplementation ameliorates statin‐induced myopathy remain

Public scholarly dataCitation signal: 129
observational

A meta-analysis of RCTs suggests that some dietary supplements could beneficially modulate sperm quality parameters and affect male fertility.

Public scholarly dataCitation signal: 126
observational

Three‐month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity.

Coenzyme Q10
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