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Public-ready7/4/2026

Citrulline

Papers analyzed
76
Exercise performance and recoveryBlood pressure and vascular health markersGlucose and metabolic health markers

Main benefit evidence

Review human evidence by goal.

Exercise performance and recovery
Exercise performance and recovery
Goal tierC
Direct human evidence
Some accumulation3 direct studies
Positive
1
No clear difference
2
Mixed
0
Negative
0
Positive study ratio33%
This is the share of verified direct studies with a positive result, not your personal chance of benefit.
Research intake observed
One study used 2.4 g/day.
Dose confirmed in 1 of 3 direct studies.
View study intake details
2.4 g/day
rct
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Blood pressure and vascular health
Blood pressure and vascular health markers
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

2 human studies in a specific clinical context are available separately.

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Glucose and metabolic health
Glucose and metabolic health markers
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

1 human studies in a specific clinical context are available separately.

Check this goal in more detail
Fatigue and energy
Fatigue and energy
Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

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Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Stomach discomfort1 papers
Stomach discomfort was reported as a side effect in 14.63% of subjects following a single 8g dose of citrulline malate.Human studies · Randomized controlled trial
Citrulline
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