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Tier-BPublic-ready6/30/2026

Chromium

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

The 63.9 score includes research signals from patient or disease contexts. General supplement evidence is not repeated enough, so the B tier remains conservative.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
73
Caution signal
Low
Context-specific research signal
63.9
Glucose and metabolic health markersBlood pressure and vascular health markersCholesterol and triglycerides

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
13 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
66.5
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood pressure and vascular health
1 studiesTier-C
Blood pressure and vascular health markers
Some positive signal observedResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
3 studiesTier-C
Cholesterol and triglycerides
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
28.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
36.08
mcg/day
Higher observed study value
1000
mcg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
1.0
Caution band: Low
Caution signals
8
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Toxicity mechanisms via transcriptomic changes1 papers
The review proposes underlying toxicity mechanisms of Chromium exposure through dermal contact, inhalation, and ingestion based on transcriptomic data and bioinformatic analyses.Human studies · Systematic review
Renal toxicity1 papers
Chromium intoxication induces significant renal toxicity characterized by oxidative stress, inflammation, apoptosis, and histological damage in rats.Animal studies · Study type not identified
Chromium toxicity and remediation1 papers
Chromium, especially hexavalent chromium, is a hazardous carcinogenic element that negatively affects human health, crop growth, and the environment, with toxicity dependent on speciation.Human studies · Systematic review
Chromium toxicity1 papers
The review identifies chromium as a toxic heavy metal causing systemic and organ complications, noting that while chelating agents are the main antidotes for heavy metals, specific interventions for chromium toxicity are required and new agents are under investigation.Human studies · Systematic review
Apoptosis and Cell Viability1 papers
Hexavalent chromium exposure induces significant cell death and apoptosis in human renal cells via reactive oxygen species generation and caspase activation.Cell studies · Study type not identified
Genotoxicity1 papers
Inorganic chromium chloride hexahydrate at 0.3 mg/kg caused significant genetic damage in fish erythrocytes as measured by comet assay parameters.Animal studies · Study type not identified
Adverse effect signal1 papers
Chromium picolinate and chromium nanoparticles were reported to increase caspase 3 and 8 levels in rats, indicating a pro-apoptotic effect.Human studies · Study type not identified
Adverse effect signal1 papers
Chromium compounds, particularly chromium-methionine and chromium nanoparticles, were observed to stimulate the immune system and increase inflammatory mediators such as IL-6, TNF-α, IgA, and IgE in rats.Human studies · Study type not identified

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 2462
review

Comparison of the mechanisms of action of heavy metals reveals similar pathways for these metals to induce toxicity including ROS generation, weakening of the antioxidant defense, enzyme inactivation, and oxidative stress.

Key Evidence #2
Public scholarly dataCitation signal: 629
review

Several studies have shown that chromium is a toxic element that negatively affects plant metabolic activities, hampering crop growth and yield and reducing vegetable and grain quality, so it must be monitored in water, soil, and crop production system.

Key Evidence #3
Public scholarly dataCitation signal: 485
review

This work critically presents their advantages and disadvantages, suggesting a site-specific and accurate evaluation for choosing the best available recovering technology for chromium removal.

3 more summariesLimited representative sample by study type.
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Public scholarly dataCitation signal: 306
observational

It was concluded that the formulation having a coating level of 50% w/w of core and weight ratio of ethyl cellulose to Eudragit L 100 showed lesser release profile as compared to other formulation, as well as better entrapment of drug leading to controlled rel

Public scholarly dataCitation signal: 179
observational

The results of this study clearly show that the fish experienced OS as characterized by significant modulation of enzyme activities, induction of DNA damage and microscopic morphological changes in the liver and kidney.

Public scholarly dataCitation signal: 176
observational

There was a strong association between incidence and mortality risk of cancers and concentration of Cr(VI) in the air and the exposure time, and it is related to increased risk of overall mortality owing to lung, larynx, bladder, kidney, testicular, bone, and

Chromium
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