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Public-ready7/5/2026

Ashwagandha

Papers analyzed
126
Stress Response and Sleep ChangesExercise performance and recoveryCognition, memory, and focus

Main benefit evidence

Review human evidence by goal.

Stress and mood
Stress Response and Sleep Changes
Goal tierA
Direct human evidence
Sufficiently accumulated6 direct studies
Positive
5
No clear difference
0
Mixed
1
Negative
0
Positive study ratio83%
This is the share of verified direct studies with a positive result, not your personal chance of benefit.
Research intake observed
One study used 700 mg/day.
Dose confirmed in 1 of 6 direct studies.
View study intake details
700 mg/day
rct
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Exercise performance and recovery
Exercise performance and recovery
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Cognition and focus
Cognition, memory, and focus
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Glucose and metabolic health
Glucose and metabolic health markers
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Men's health
Male Reproductive Health Markers
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
8
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Hepatotoxicity1 papers
The review identifies Withania somnifera (Ashwagandha) as a commonly used herbal component with inherent hepatotoxicity potential that can lead to acute liver failure.Human studies · Systematic review
Liver injury1 papers
This case series describes suspected ashwagandha-induced liver injury in patients.Human studies · Observational study
Adverse effect signal1 papers
The study reported that 70% ethanol ashwagandha root extracts modulated CYP3A4 enzyme expression and activity in primary human hepatocytes, highlighting potential risks for co-administration with prescribed drugs.Cell studies · Study type not identified
Adverse effect signal1 papers
Preliminary studies observed dose- and time-dependent cytotoxic effects on hepatocyte viability at high concentrations of 70% ethanol ashwagandha leaf extracts.Cell studies · Study type not identified
Gastrointestinal issues1 papers
Some studies included in the review report gastrointestinal issues associated with Ashwagandha supplementation.Human studies · Systematic review
Adverse effect signal1 papers
The review states that potential interactions with medications are reported, necessitating caution and consultation with healthcare providers.Human studies · Study type not identified
Treatment-emergent adverse events (nausea, abdominal pain, drowsiness)1 papers
Seven participants in the Ashwagandha group reported mild adverse events including nausea, abdominal pain, and drowsiness, which resolved without intervention.Human studies · Randomized controlled trial
Gastrointestinal-related adverse events1 papers
Gastrointestinal-related adverse events were reported in 53 participants in the Withania somnifera arm, described as excellent tolerability overall.Human studies · Randomized controlled trial
Ashwagandha
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